This Symposium focuses on the synthesis, characterization, and performance (both in vitro and in vivo) of coatings and modified surfaces designed for biomedical applications (biomaterials, bioimplants, biosensors, general health care, etc.). The symposium will be devoted to creating a platform, a friendly hub, to promote some research discussions between material scientists, coating performers, and clinicians. Papers are solicited in areas related to: bioactive and biocompatible coatings for implants (orthopedic, dental, spinal, etc.), cardio-vascular stents, drug delivery and biosensing; hydroxyapatite coatings; biomimetic and bio-inspired coatings; anti-bacterial, anti-biofouling and eluting coatings; blood-compatible coatings; electrospun coatings; biofunctionalization of materials surfaces such as tissue engineering scaffolds by wet chemical and plasma methods; cell-surface interactions; bio-lubrication and bio-tribology; and processing and characterization of biomaterial surfaces. Concerning the interactions between the coating and the medium, some investigations were dedicated to studying the corrosion degradation of the substrate. Moreover, some opening fields are focused on the effect of the coating on the biological behavior, as cells growth, cells adhesion, etc. Some contributions in the fields of retrieval implant analysis, the release of metal ions/particles, smart/intelligent surfaces and potential clinical concerns will be also considered. A new key interest is 3D printing. Additive manufacturing requires most of the time some surface coatings to promote osseointegration and more generally biocompatibility. The D Symposium will have a look at this new area.
D1. Surface Coating and Surface Modification in Biological Environments
This session is dedicated to coatings as well as surface modifications for use in biomedical applications in order to improve performance characteristics or to add additional functions to an implant or surgical instrument. The functionalities of these coatings/surface modifications should focus on the improvement of one or more attributes such as biocompatibility, cell proliferation and growth, suppression of restenosis, thrombus formation, antimicrobial behavior and metallic ion release, load-bearing prostheses, corrosion resistance, wear resistance, etc. under in vitro and in vivo conditions.
D1 Invited Speakers:
- Mozart Q. Neto, Rush University Medical Center, USA, “Microstructural and Electrochemical Characterization of 3D Printed Biomedical Implants”
- Rene Olivares-Navarrete, Virginia Commonwealth University, USA, “Surface Properties Control Immune Response to Implanted Biomaterials”
D2. Medical Devices: Bio-Tribo-Corrosion, Diagnostics, 3D Printing
Metallurgical materials are essential components of medical devices used to restore biological function, detect or respond to physiological or external stimuli, or modulate the response of cells at interfaces. This session seeks to explore clinical applications and physiological responses to material systems used for tissue regeneration, implantable sensors, and smart drug delivery, among others. Fabrication and testing of these materials using additive manufacturing technologies are of particular interest. Research is solicited that evaluates biological reactions to implant surface coatings as well as methods of depositing coating particles of varying size and composition. Release of molecules or particles from surfaces, either intentionally or due to wear and corrosion processes is also an area of interest.
D2 Invited Speaker:
D3. Biointerfaces: Improving the Cell Adhesion and Avoiding Bacteria. What Kinds of Coatings/Surfaces Should be Used?
What Kinds of Coatings Should be Used? Interaction between cells and biomaterials occurs via the surface characteristics of the material, which include their topography, chemistry, mechanical properties or surface energy. These interactions trigger desired or undesired processes. For example, they can induce signaling pathways to regulate cell adhesion, migration, proliferation and differentiation into specific phenotypes desirable for the application. However, they might also promote excessive adhesion of microorganisms forming biofilms that can lead to signiﬁcant health risks. Such interactions are greatly determined by the initial protein adsorption that occurs in a shorter time scale. Understanding all these interaction processes and their correlation with the surface properties is key knowledge that will allow us to design novel surfaces or coatings to promote specific biological responses, i.e. design bioactive surfaces.
D3 Invited Speaker:
- Sami Rtimi, Ibticare Group, Switzerland, “Catalytic Reactions at the Interface Thin Film/Bacteria: Dynamics, Characterization and Mechanisms”